Page 373 - Resúmen - XXV Congreso Latinoamericano de Parasitología - FLAP

S3-46

Molecular prevalence of bovine ehrlichiosis: a global systematic review and

meta- analysis

Bonilla-Aldana, D. Katterine ; Quintero-Rada, Keidenis ; Montoya-Posada, Juan Pablo ;
1
1
1
Rodriguez Morales, Alfonso J. 2
1 Semillero de Grupo de Investigación BIOECOS, Fundación Universitaria Autónoma de las Américas,
Pereira, Risaralda, 660004, Colom; Universidad Tecnológica de Pereira
2

Introduction: Ehrlichia species are able to infect cattle, in addition to species belonging to the
genus Anaplasma. Albeit that, E. ruminatium and E. minasensis, are species that are not well known, even
among veterinarians. Given the low knowledge on bovine ehrlichiosis, and no previous systematic reviews
and meta-analysis about that, we collected studies in order to assess the molecular prevalence globally.
Methods: We performed a literature systematic review in six databases (Web of Sciences/
Scopus/PubMed/SciELO/Lilacs/Google Scholar) to assess the molecular prevalence of cattle to Erhlichia.
A meta-analysis with random-effects model was performed to calculate the pooled prevalence, and 95%
confidence intervals (95%CI). Measures of heterogeneity (Cochran's Q-statistic, I2 index, and τ2 test), were
reported. Subgroup analyses were conducted by Erhlichia species, country and regions. Results: Till
August 1, 2019, the literature search yielded 1051 articles, of which 71 studies were fully valid for analysis.
The pooled molecular prevalence for Erhlichia at individual level (N=6,232) was 2.3% [95%CI(1.7%-
2.9%);τ2=0.001;I2=81.944;Q=387.685; p<0.001], highest value 82.4% (China, 2016). Studies identified the
highest pooled molecular prevalence for E.canis of 6.6% [95%CI(0.6%-12.7%);I2= 90.74;Q=43.208;
p<0.001]. Followed by E.ruminantium (n=4,695 [75.33%] 52 studies) with 1.7% [95%CI(1.1%-
2.3%);I2=77.29;Q=224.569;p<0.001]. For E.chaffensis, 1.5% [95%CI(0.0%-0.3%);I2=60.96; Q=12.806;
p=0.025]. For E.minasensis, only one study was included (3%). The country with highest prevalence was
Grenada (1), 50%, followed Saint Kitts (1) 25.7%, and Dominica (1) 14.1%. In China, with 18 included
studies, mol-prevalence was 1.8% [95%CI(0.7%-3.0%);I2=87.54;Q=136.50;p<0.001]. Asia (18 studies) and
Africa (48) contributed most. Africa mol-prevalence was 1.8% (95%CI 1.1%-2.4%). Americas (5) yield
13.2% (95%CI 0.6%-27.0%). Twelve studies were in Bos taurus and four in Bos indicus.
Conclusions: Heartwater (E.ruminantium) is a notifiable disease that is listed by the World Organization
for Animal Health. The risk that endemic heartwater could become established in the Americas is very real
given the climate. Also, E.minansensis, E.chaffensis and even E.canis, have been detected in cattle.

371
RESÚMENES DE CARTELES